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Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy

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Author(s): Jeter Ashley | Kang Yubin

Journal: Experimental Hematology & Oncology
ISSN 2162-3619

Volume: 1;
Issue: 1;
Start page: 20;
Date: 2012;
Original page

Keywords: Bortezomib | Peripheral neuropathy | Immune modulation | Multiple myeloma

ABSTRACT
Abstract Peripheral neuropathy (PN) is one of the most common side effects of bortezomib therapy. The majority of bortezomib-related PN is a sensory neuropathy of mild to moderate degree, and is reversible after dose reduction or discontinuation. However, occasionally bortezomib-induced neuropathy can be severe and affects motor and/or autonomic nerves, and may be mediated by immune process. The role of immune modulation therapy in the management of bortezomib-induced PN was not well established. Here, we reported a case of bortezomib-induced severe PN that responded well to plasma exchange and steroid treatment.
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