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Immunogenetic aspects of pathogenesis of chronic HCV-infection (review)

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Author(s): KHAMID KARIMOV | SEVARA AZIMOVA | BAKHTIYOR IRISKULOV

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 4;
Start page: 18;
Date: 2012;
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Keywords: Chronic Hepatitis | Hcvinfection | Pathogenesis | Immunogenetic Factors | CTLA4 Gene

ABSTRACT
Viral hepatitis B and C is a relevant issue because of high prevalence and degree of chronicity, late diagnosis and poorprognosis. Today, protein products of numerous genes are involved in the pathogenesis of viral pathology of the liver. Inthis review, the authors analysed 42 literature sources on genetic basis of susceptibility to various infectious diseases.Study of the role of immunogenetic factors is of great practical importance to develop methods for predicting outcomes ofviral hepatitis.

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