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Immunohaematological reference values for HIV-negative healthy adults in Botswana

Author(s): Madisa Mine | Sikhulile Moyo | Penny Stevens | Kurt Michael | Vladimir Novitsky | Kgomotso Makhaola | Aida Asmelash | S’khatele Molefhabangwe | Elias Woldegabriel | Gaseboloke Mothowaeng | Talkmore Maruta | Charity Kamhukamwe | Phibeon M. Mangwendeza | Molly Holmes-Pretorius | Isaac Mtoni | Modisa Motswaledi | Rosemary Musonda | Ndwapi Ndwapi | Joseph Makhema | Richard Marlink | Khumo Seipone | Tendani Gaolathe | Max Essex

Journal: African Journal of Laboratory Medicine
ISSN 2225-2002

Volume: 1;
Issue: 1;
Date: 2011;
Original page

Keywords: Botswana | HIV-negative | Immunohaematology | reference intervals | T-lymphocytes

Background: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers’ kits and textbooks. Objectives: The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana.Method: A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured.Results: The mean age was 28.8 (95% Confidence Interval [CI] 27.7–29.8) years, with a median of 27 years and a range 18–66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% – 12.7%) than men (15.1 g/dL; 95% CI 14.9% – 15.3%). The women’s haemoglobin reference values (9.0 g/dL – 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL – 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL – 15.8 g/dL) recently defined for East and Southern Africa.Conclusion: The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally.
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