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Immunomodulatory activity of methanolic extracts of Pongamia glabra Vent. seeds and bark in cyclophosphamide induced mice

Author(s): Sanjeev Heroor, Arunkumar Beknal, Nitin Mahurkar

Journal: RGUHS Journal of Pharmaceutical Sciences
ISSN 2249-2208

Volume: 2;
Issue: 1;
Start page: 74;
Date: 2012;
Original page

Immune activation is an effective as well as a protective and novel approach against emerging infectious diseases. Traditionally Pongamia glabra Vent claimed to cure infectious diseases needs scientifi c validation as immunomodulatory agent. Methanolic extracts of seeds and barks at the doses of 250 mg/kg and 500 mg/kg (per oral) of Pongamia glabra Vent. were studied for the assessment of immunomodulatory activity on cyclophosphamide induced immunosuppression in mice. The activity was assessed by determining the RBC, Hb%, platelet, total WBC and differential counts. Methanolic extracts of seeds and barks of Pongamia glabra Vent. showed dose dependent highly signifi cant counteracting effect (p
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