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Impact of maternal vitamin D status during pregnancy on the prevalence of neonatal vitamin D deficiency

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Author(s): Mohamed A. El Koumi | Yasser F. Aly | Rehab N. Abd El Rahman

Journal: Pediatric Reports
ISSN 2036-749X

Volume: 5;
Issue: 1;
Date: 2013;
Original page

Keywords: Maternal vitamin D deficiency | Neonatal 25-Hydroxyvitamin D3 | calcium homeostasis

ABSTRACT
Background: Maternal vitamin D deficiency is not uncommon. The lack of vitamin D during pregnancy may results in poor fetal growth and altered neonatal development that may persist into later life. Recognition of risk factors and early detection of vitamin D deficiency during pregnancy is important in order to prevent neonatal vitamin D deficiency and related complications. Objective: The aim of the study is to assess the effect of maternal vitamin D status on neonatal vitamin D stores. Study design: A total of 92 pregnant women at 30 -37 weeks gestation and their newborns were recruited from Al Khafji Joint Operation Hospital, KSA during the year 2011 .Maternal and cord blood samples were taken for determination of serum levels of circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration , serum calcium (Ca++) , phosphorus (PO4) and alkaline phosphatase (ALP). Results: Compared with pregnant women with adequate vitamin D levels; women deficient in vitamin D had infants with vitamin D deficiency (X± SD 33.44±18.33 nmol/L vs. 55.39±17.37 nmol/L, p=0.01). Maternal and neonatal serum 25(OH)D3 levels showed a positive correlation with serum Ca++ and negative correlation with serum PO4 and ALP. Neonatal 25(OH)D was related to maternal third trimester levels (r = 0.89 , p= 0.01). Conclusion: The newborn serum 25(OH)D3 concentrations are reliant on maternal vitamin D status and the poor maternal vitamin D status may adversely affect neonatal calcium homeostasis.
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