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Influence of Glutamic Acid on the Properties of Poly(xylitol glutamate sebacate) Bioelastomer

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Author(s): Weifu Dong | Ting Li | Shuangfei Xiang | Piming Ma | Mingqing Chen

Journal: Polymers
ISSN 2073-4360

Volume: 5;
Issue: 4;
Start page: 1339;
Date: 2013;
Original page

Keywords: xylitol | glutamic acid | bioelastomers | property

ABSTRACT
In order to further improve the biocompatibility of xylitol based poly(xylitol sebacate) (PXS) bioelastomer, a novel kind of amino acid based poly(xylitol glutamate sebacate) (PXGS) has been successfully prepared in this work by melt polycondensation of xylitol, N-Boc glutamic acid and sebacic acid. Differential scanning calorimetry (DSC) results indicated the glass-transition temperatures could be decreased by feeding N-Boc glutamic acid. In comparison to PXS, PXGS exhibited comparable tensile strength and much higher elongation at break at the same ratio of acid/xylitol. The introduction of glutamic acid increased the hydrophilicity and in vitro degradation rate of the bioelastomer. It was found that PXGS exhibited excellent properties, such as tensile properties, biodegradability and hydrophilicity, which could be easily tuned by altering the feeding monomer ratios. The amino groups in the PXGS polyester side chains are readily functionalized, thus the biomelastomers can be considered as potential biomaterials for biomedical application.
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