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INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION

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Author(s): Faegheh Khoshkhahesh | Marefat Siahkuhain | Gordon Fisher | Babak Nakhostin-Roohi

Journal: Biology of Sport
ISSN 0860-021X

Volume: 30;
Issue: 1;
Start page: 61;
Date: 2013;
Original page

Keywords: muscle damage | Inflammation | celecoxib

ABSTRACT
The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% ·VO2max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P
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