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Inhibitation of A549 cells induced by tetrandrine with MTT assay

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Author(s): Xinhui Jiang | Yongzhen Teng | Kaishun Huang | Qixin Zhou

Journal: Scientific Journal of Frontier Chemical Development
ISSN 2167-163X

Volume: 2;
Issue: 1;
Start page: 18;
Date: 2012;
Original page

Keywords: MTT | Tetrandrine | lung adenocarcinoma A549 cell | proliferation.

ABSTRACT
Objective To study the ability of tetrandrine to inhibit the human lung adenocarcinoma A549 cell and whether tetrandrine may be used in lung cancer patients’ chemotherapy. Methods The ability of tetrandrine to inhibit cells was detected by the MTT method. Results The IC50 of tetrandrine to A549 were 8.57 ?g/mL, 6.25 ?g/mL, 4.43 ?g/mL,for 24 h, 36 h, 48 h, respectively. Conclusion Different concentrations of tetrandrine on lung adenocarcinoma A549 cells inhibit the proliferation and showed significant time and dose-effect relationship. Tetrandrine in vitro can inhibit the growth of A549 lung cancer cells.
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