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Inhibition of Immediate-Type Allergic Reaction by 4-Arylcoumarin

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Author(s): Thongchai Taechowisan | Chunhua Lu | Yuemao Shen | Saisamorn Lumyong

Journal: Research Journal of Immunology
ISSN 1994-7909

Volume: 1;
Issue: 1;
Start page: 1;
Date: 2008;
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Keywords: 4-arylcoumarins | immediate-type allergic reaction | mast cells | tumor necrosis factor-α | interleukin-6

ABSTRACT
We studied the effect of 4-Arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as pretreatment, at concentrations ranging from 0.001 to 1 g kg1, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-α and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.
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