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Inhibitory Effect of Sulforaphane against Benzo(a)pyrene Induced Lung Cancer by Modulation of Biochemical Signatures in Female Swiss Albino Mice

Author(s): D. Kalpana Deepa Priya | R. Gayathri | G.R. Gunassekaran | S. Murugan | D. Sakthisekaran

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 6;
Issue: 5;
Start page: 395;
Date: 2011;
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Keywords: carcino- embryonic antigen | metabolic state | sub cellular derangement | biochemical signatures | sulforaphane | Chemoprotection | Ki67

-1 b.w., i.p.) induced experimental lung carcinogenesis. The sub cellular derangements were assessed by the cytotoxic and cellular functional markers, lysosomal enzyme leakage and enzymes of nucleic acid metabolism. The concept of free radicals contributing to carcinogenesis was confirmed by evaluating thioredoxin reductase and heme oxygenase. The carcinogenic biomarkers were complemented by immunohistochemical analysis of cell proliferating nuclear antigen-Ki67 and measurement of serum carcinoembryonic antigen by ELISA. Our work proves the chemoprotective potential of sulforaphane in vivo against cellular derangements caused by B(a)P in the process of carcinogenesis.]]>
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