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Insights on the structural characteristics of NDM-1: The journey so far

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Author(s): Avneet Saini | Rohit Bansal

Journal: Advances in Biological Chemistry
ISSN 2162-2183

Volume: 02;
Issue: 04;
Start page: 323;
Date: 2012;
Original page

Keywords: NDM-1 | Metallo-β-Lactamase | Superbug | β-Lactam | Extended-Spectrum β-Lactamases

ABSTRACT
New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide is now considered a nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies is structural characterization as knowledge of the three-dimensional structure of NDM-1 shall help find connections between its structure and function. Moreover, structural details are even critical in order to reveal the resistance mecha- nism to β-lactam antibiotics. In this perspective, we review structural characteristics of NDM-1 that have been delineated since its first report. We anticipate that these structure-function connections made by its characterization shall further serve as future guidelines for elucidating pathways towards de novo design of functional inhibitors.
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