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Insulin growth factor-1 and insulin growth factor binding protein-3 in Egyptian patients with chronic hepatitis C

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Author(s): Hala Mohamed Raslan | Wafaa Mohamed Ezzat | Mohamed Mahmoud Ahmed | Enas Abdel Rasheed

Journal: Archives of Medical Science
ISSN 1734-1922

Volume: 3;
Issue: 1;
Start page: 46;
Date: 2007;
Original page

Keywords: IGF-1 | IGFBP-3 | chronic hepatitis | liver cirrhosis

ABSTRACT
Introduction: The liver is the major source of insulin growth factor-1 (IGF-1) and its main binding protein, insulin growth factor binding protein-3 (IGFBP-3), which modify its bioavailability, and their concentrations might reflect liver synthetic capacity. The aim of the study was to evaluate serum levels of IGF-1 and IGFBP-3 in patients with chronic hepatitis C and their potential use as a marker of hepatic synthetic capacity. Material and methods: Thirty patients with chronic hepatitis C virus infection were included in the study: 16 patients with chronic hepatitis and 14 patients with liver cirrhosis. Thirteen healthy volunteers, age and sex matched with the cases, were used as a control group. Serum IGF-1 and IGFBP-3 were measured in all patients and controls by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of IGF-1 in patients with liver cirrhosis were significantly lower than those in patients with chronic hepatitis and those in healthy controls (110.4±57 ng/ml, 308.1±188.5 ng/ml and 274.1±81.6 ng/ml respectively, p
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