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Integrins – a Relevant Target in Glioblastoma

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Author(s): Xiaosi Han | L B Nabors

Journal: European Journal of Clinical & Medical Oncology
ISSN 1759-8958

Volume: 2;
Issue: 1;
Start page: 59;
Date: 2010;
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ABSTRACT
Integrins are cell surface molecules that are important for the interaction of cells with the extracellular environment. Crucial for cell survival and migration, integrins have been recognized as a unique target for central nervous system cancers. In the most malignant of these, glioblastoma multiforme (GBM), integrins have key roles in supporting robust tumor angiogenesis as well as facilitating the survival, migration and infiltration of transformed tumor cells into the brain itself. The anti-integrin activity of several compounds that target the tumor and its environment has been tested in early phase clinical trials in patients with malignant brain cancer. This review outlines the function of integrins and the current state of clinical investigation.
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