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Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons

Author(s): Zixian Lu

Journal: Advances in Biological Chemistry
ISSN 2162-2183

Volume: 02;
Issue: 03;
Start page: 301;
Date: 2012;
Original page

Keywords: Nonsense Suppression | Codon Nonsense Mutation | Suppressor tRNAs

Codon nonsense mutations include amber, ochre, or opal mutations according to termination codon consisting of three types (TAG, TAA and TGA). Codon nonsense mutations are also divided into natural and artificial mutations. We discussed the interaction of codon nonsense mutations and suppressor tRNAs in vitro and in vivo. Nonsense suppressions do not only happen in prokaryotes but also in eukaryotes. Meanwhile, the misreading of termination codon and in-corporation of nonnatural amino acids into proteins are also introduced.
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