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INVESTIGATION OF EFFECTS OF PIOGLITAZONE, GLIMEPIRIDE, NOBIVOLOL, VALSARTAN AND HESPERIDINE ON GLUCOSE, HBA1C AND LACTATE DEHYDROGENASE IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN NORMAL AND DIABETIC RATS

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Author(s): Jagdish Kakadiya | Dr. Nehal Shah

Journal: Journal of Innovative Trends in Pharmaceutical Sciences
ISSN 0975-8593

Volume: 1;
Issue: 3;
Start page: 144;
Date: 2010;
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Keywords: Lactate dehydrogenase | Glucose | HbA1c | cardioprotective

ABSTRACT
Present study was designed to evaluate effect some synthetic drugs and some herbal compound on Glucose, HbA1c and lactate dehydrogenase (LDH) in isoproterenol induced myocardial infarction in normal and Streptozotocin-Nicotinamide induced diabetic in rats. Pioglitazone (10 mg/kg, p.o), Glimepiride (0.5 mg/kg, p.o), Nobivolol (2 mg/kg, p.o), Valsartan (8 mg/kg, p.o) and Hesperidin (100 mg/kg, p.o) were administered for 28 days in rats injected with single dose of Streptozotocin (65 mg/kg, i.p, STZ) and Nicotinamide (12mg/kg, i.p, NIC) and after isoproterenol (200 mg/kg, s.c.) induced myocardial infarction in rats on 29th and 30th day. At the end of experimental period (i.e. on the day 31) blood samples were collected and animals were euthanized. Separated Serum of each rat was collected and glucose, HbA1c and LDH carried out for further estimations. Administration of STZ–NIC in rats showed a significant (p
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