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Investigation of the Relationship between Retinol Binding Protein 4 and Metabolic Syndrome and Insulin Resistance in Iranian Obese 5-17 Year Old Children

Author(s): Forough Saki | Soheil Ashkani-Esfahani | Zohreh Karamizadeh

Journal: Iranian Journal of Pediatrics
ISSN 1018-4406

Volume: 23;
Issue: 4;
Start page: 396;
Date: 2013;
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Keywords: Retinol Binding Protein 4 | Insulin Resistance | Metabolic Syndrome | Obesity | Children

Objective: Retinol-binding protein 4 (RBP4) has recently been reported to be associated with insulin resistance (IR) and the metabolic syndrome by a number of researchers in various populations. However, controversies are present among different studies, which might be due to the differences between various ethnic, age, and sex groups. This study aimed to determine whether RBP4 can be assumed as a marker of IR and the metabolic syndrome in the Iranian obese children.Methods: In the present longitudinal cross-sectional study, 100 5-17 years old obese children were recruited from January 1, 2011 to February 1, 2012. The patients’ information including the demographic variables, health status and behavior, and daily physical activity were collected. Moreover, serum RBP4 was measured and correlated with the homeostasis model assessment of IR index (HOMA-IR), components of the metabolic syndrome, and lipoprotein metabolism.Findings: The results revealed a positively significant correlation between RBP4 and the HOMA-IR index (P=0.02). Partial Spearman test also revealed a significant correlation between RBP4 plasma concentrations and the components of the metabolic syndrome, including waist circumference, systolic (but not diastolic) blood-pressure, and fasting blood sugar (P
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