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L-asparaginase- Types, Perspectives and Applications

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Author(s): Dhanam Jayam G | Kannan S

Journal: Advanced Biotech
ISSN 0973-0109

Volume: 13;
Issue: 05;
Start page: 01;
Date: 2013;
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Keywords: Enzymes | L-asparaginase

ABSTRACT
Enzymes are protein molecules consists of amino acid chains, produced by all living organisms. In our human body, enzymes play a major role by its catalytic action. Each enzyme is programmed to carry out a special task. Enzymes produced from microorganisms play a major role in the diagnosis and curing of many dreadful diseases in man One among the disease is Leukemia. For leukemia, the enzyme L-asparaginase act as a barrier i.e., by injecting the enzyme L-asparaginase, the substrate L-asparagine which is essential for the growth of tumor cells can be reduced and the tumor proliferation can be prevented. L-asparaginase is a typical oncolytic enzyme plays a major role in acute lymphoblastic leukemia (ALL). The L-asparaginase enzyme degrade the Lasparagine present in blood circulation and indirectly starve tumor cells and leads to cell death. i.e., Lasparaginase catalyses the conversion of L-asparagine to aspartic acid and ammonia and thereby prevents the tumor cells from rapid malignant growth. The enzyme can be produced from various plants, animals, bacterial and fungal sources. With this background the present review is an attempt to compile information on the sources, mechanism, molecular details and application of L-asparaginase enzyme..
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