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Light chain deposition disease; there are reasons for confusion

Author(s): Ardalan Mohammad-Reza

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 4;
Start page: 127;
Date: 2013;
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Keywords: Light chain deposition disease | Plasma cell dyscrasia | Glycosuria

Implication for health policy/practice/research/medical education:Congo red negative nodular deposition of an amorphous, eosinophilic material is the most common pathologic finding in light chain deposition disease in light microscopy. The nodules are a mixture of light chain and mesangial protein and the picture is reminiscent of diabetic nephropathy. Immunoflurescent microscopy usually demonstrates the presence of monotypic kappa light chain. It seems that serum creatinine level greater than 4 mg/dl is a poor prognosis sign for future progress to end stage renal disease in this disease. Therefore, early diagnosis is important.
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