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Low pre-operative levels of serum albumin predict lymph node metastases and ultimately correlate with a biochemical recurrence of prostate cancer in radical prostatectomy patients

Author(s): Takehiro Sejima | Hideto Iwamoto | Toshihiko Masago | Shuichi Morizane | Akihisa Yao | Tadahiro Isoyama | Hiroyuki Kadowaki | Atsushi Takenaka

Journal: Central European Journal of Urology
ISSN 2080-4806

Volume: 66;
Issue: 02;
Start page: 126;
Date: 2013;
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Keywords: prostatic cancer | radical prostatectomy | prostate–specific antigen | recurrence | serum albumin

Introduction. To date, only few studies focusing on the issue of host general and immune activity have been performed in localized prostate cancer (PCa). The aim of this study was to elucidate potent non tumor–related biomarkers that express aggressiveness of PCa treated by radical prostatectomy (RP).Materials and methods. Data from 179 patients who underwent RP were analyzed. The correlations between various kinds of non tumor–related factors in addition to tumor–related factors and biochemical recurrence (BCR) were analyzed. The correlations between pre–, intra– and post–operative factors were also analyzed. Results. Thirty–two cases (17.9%) had a BCR. The factors found to be significantly predictive of BCR using a Cox–proportional hazard model were the pre–operative serum prostate specific antigen (PSA) level and the existence of pathological lymph node metastasis (LNM). A low pre–operative serum albumin level (

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