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Matrix Metalloproteinase Enzyme Family

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Author(s): Ozlem Goruroglu Ozturk

Journal: Arsiv Kaynak Tarama Dergisi
ISSN 1300-3755

Volume: 22;
Issue: 2;
Start page: 209;
Date: 2013;
Original page

Keywords: Collogenase | gelatinase | matrix metalloproteinase | tisue inhibitors

ABSTRACT
Matrix metalloproteinases play an important role in many biological processes such as embriogenesis, tissue remodeling, wound healing, and angiogenesis, and in some pathological conditions such as atherosclerosis, arthritis and cancer. Currently, 24 genes have been identified in humans that encode different groups of matrix metalloproteinase enzymes. This review discuss the members of the matrix metalloproteinase family and their substrate specificity, structure, function and the regulation of their enzyme activity by tissue inhibitors. [Archives Medical Review Journal 2013; 22(2.000): 209-220]
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