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Metformin and renal injury protection

Author(s): Rafieian-Kopaie Mahmoud

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 2;
Issue: 3;
Start page: 91;
Date: 2013;
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Keywords: Metformin | Diabetic nephropathy | Kidney

Implication for health policy/practice/research/medical education:Metformin protects against tubular injury by modulation of oxidative stress on the tubules and restoring the biochemical alterations. While in diabetes, glycosuria causes tubular cell injury. Furthermore metformin is able to protect podocytes in diabetic nephropathy. These findings may suggest the clinical use of metformin in the prevention of diabetic nephropathy.
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