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Method development for spherical crystallization of glibenclamide and evaluation of micromeritic properties

Author(s): Vinay K. Mishra1, Sumeet Dwivedi2*, Parivesh Sakalle3, Gunjan Jain3, Daksha Gupta3 and Divya Gupta3

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 2;
Start page: 119;
Date: 2010;
Original page

Keywords: Glibenclamide | Crystallization | Micromeritic properties

Glibenclamide is an anti-diabetic drug with water insolubility and compressibility. The pure drug (Glibenclamide) was converted into spherical crystal agglomerates via the spherical crystallization technique using dichloromethane-water-chloroform solvent system. The various parameters optimized were type, amount and mode of addition of bridging liquid, temperature and agitation speed to get maximum amount of spherical crystals. These were characterized for micromeritic properties (particle size and shape, flow ability), pack ability (bulk density), wet ability (contact angle) and compressibility. It was revealed from the study that spherical agglomerates exhibited improved flow ability, wet ability and compaction behavior.
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