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Micelle Enhanced Fluorimetric and Thin Layer Chromatography Densitometric Methods for the Determination of (±) Citalopram and its S – Enantiomer Escitalopram

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Author(s): Elham A. Taha | Nahla N. Salama | Shudong Wang

Journal: Analytical Chemistry Insights
ISSN 1177-3901

Volume: 4;
Start page: 1;
Date: 2009;
Original page

Keywords: citalopram | escitalopram | micelle fluorimetry | spiked plasma | thin layer chromatography densitometry | chiral selectors

ABSTRACT
Two sensitive and validated methods were developed for determination of a racemic mixture citalopram and its enantiomer S-(+) escitalopram. The first method was based on direct measurement of the intrinsic fluorescence of escitalopram using sodium dodecyl sulfate as micelle enhancer. This was further applied to determine escitalopram in spiked human plasma, as well as in the presence of common and co-administerated drugs. The second method was TLC densitometric based on various chiral selectors was investigated. The optimum TLC conditions were found to be sensitive and selective for identification and quantitative determination of enantiomeric purity of escitalopram in drug substance and drug products. The method can be useful to investigate adulteration of pure isomer with the cheap racemic form.
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