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Mitochondrial Defects And Their Role In Development Of Prostate Cancer

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Author(s): NANULI KOTRIKADZE | MANANA ALIBEGASHVILI | LIANA RAMISHVILI | MANANA GORDEZIANI | NATO VESHAPIDZE | TEIMURAZ CHIGOGIDZE | TEIMURAZ CHIGOGIDZE

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 3;
Start page: 17;
Date: 2012;
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Keywords: Prostate Cancer | Mitochondrial defects

ABSTRACT
Introduction and Objectives: One of the characteristic changes of tumor formation is accumulation of genetic disorders inmitochondrial and nuclear genome. Mitochondrial disorders, from its side, are responsible for failure of metabolism,apoptosis, cell growth, formation of reactive oxygen species, etc. Overprpoduction of reactive oxygen species (ROS)significantly impacts the respiration chain enzymes and entirely the antioxidant system of mitochondria. Finally this maybecome a favorable condition for normal cells transformation.The purpose of the presented work was to study the mitochondrial defects and to establish their role in prostate cancerdevelopment.Results: Experimental results demonstrate significant increase of the activity of mitochondrial succinate dehydrogenaze(complex II) of the malignant epithelial cells of prostate, and slight changes in cytochrome oxydase (complex IV) activity.Also significant activation of the antioxidant system (glutathione-dependant system) of mitochondria in prostate malignantepithelial cells was revealed.Conclusion: The above mentioned mitochondrial changes (II and IV complexes of respiration chain, activity of theantioxidant system) partially demonstrate the alterations in mitochondrial energy metabolism, which from its side, mayindicate to resistance of prostate cancer cells and correspondingly to intensification of proliferation processes.
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