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Modulation of proinflammatory cytokines and leukocyte mobilization by melatonin in response to sterile tissue injury in Wistar albino rats

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Author(s): Hussein F. Sakr | Bahjat Al-Ani

Journal: Saudi Medical Journal
ISSN 0379-5284

Volume: 34;
Issue: 5;
Start page: 470;
Date: 2013;
Original page

ABSTRACT
Objectives: To test the hypothesis that the neurohormone, melatonin, differentially activates the release of the proinflammatory cytokines, such as, interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), as well as inducing leukocyte mobilization into the peripheral blood in response to a sterile tissue injury. Methods: This study was conducted between November 2011 and September 2012 at the Department of Physiology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. Sterile tissue injury of either skin injury or gastric ulceration was induced in equal numbers in Wistar albino rats aged 7-8 weeks  (150-200 g) (20 each), with each group being equally divided into melatonin treated or vehicle-treated. Results: Melatonin treatment and sterile tissue injuries significantly (p
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