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Molecular Mechanisms of Survival Strategies in Extreme Conditions

Author(s): Salvatore Magaz├╣ | Federica Migliardo | Miguel A. Gonzalez | Claudia Mondelli | Stewart F. Parker | Beata G. Vertessy

Journal: Life
ISSN 2075-1729

Volume: 2;
Issue: 4;
Start page: 364;
Date: 2012;
Original page

Keywords: survival strategies | molecular mechanisms | lysozyme | dUTPase | trehalose | structure | dynamics | spectroscopic techniques

Today, one of the major challenges in biophysics is to disclose the molecular mechanisms underlying biological processes. In such a frame, the understanding of the survival strategies in extreme conditions received a lot of attention both from the scientific and applicative points of view. Since nature provides precious suggestions to be applied for improving the quality of life, extremophiles are considered as useful model-systems. The main goal of this review is to present an overview of some systems, with a particular emphasis on trehalose playing a key role in several extremophile organisms. The attention is focused on the relation among the structural and dynamic properties of biomolecules and bioprotective mechanisms, as investigated by complementary spectroscopic techniques at low- and high-temperature values.
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