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Morphological Characteristics Of Lungs In The Dynamics Of Development Of A New Experimental Model Of Surgical Sepsis

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Author(s): YORKIN AZIZOV | ALISHER OHUNOV

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 3;
Start page: 34;
Date: 2012;
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Keywords: Surgical sepsis | Generalization of infection | Pulmonary atelectasis | Endothelial damage

ABSTRACT
This is an experimental study of lung morphology in modeling sepsis on a background of severe purulentinflammatorydisease of soft tissues (necrotizing fasciitis) by original authors' method. The study showed that early stages of sepsis (13days) were characterized by manifestations of changes in lung tissue as vascular response, in the second period (the 7thday) by appearance and growth of nonobstructivemicroatelectases, whereas the third period (the 14th day) wascharacterized by progression of purulentnecroticprocesses in soft tissues, development of surgical sepsis and acuterespiratory distress syndrome. These changes in morphological structure of lung tissue are specific for generalized septicprocess and consequences of necrotizing fasciitis with its septic complication.
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