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Multiple sequence alignment: a methodology for protein identification

Author(s): Srinivasa Rao V. | Das S. K. | Nageswara Rao K. | Kusuma Kumari E.

Journal: International Journal of Systems Biology
ISSN 0975-2900

Volume: 1;
Issue: 2;
Start page: 43;
Date: 2009;
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Keywords: Molecular Biology | Global Alignment | ClustalW

Multiple sequence alignment is the foundation of many important applications in bioinformaticsthat aim at detecting functionally important regions, predicting protein structures, building phylogenetic treesetc. Although the automatic construction of a multiple sequence alignment for a set of remotely relatedsequences cause a very challenging and error-prone task, many downstream analyses still rely heavily onthe accuracy of the alignments.
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