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Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma

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Author(s): Mehdi Dehghani | Vahid Mohammad Karimi

Journal: Middle East Journal of Cancer
ISSN 2008-6709

Volume: 3;
Issue: 2 ;
Start page: 89;
Date: 2012;
Original page

Keywords: Nephrogenic diabetes insipidus | Multiple myeloma | Lambda light chain | Amyloidosis

ABSTRACT
We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. This unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. The tubular functional disturbance appeared to be related to thepresence of lambda-type light chains. The patient was treated withdesmopressine without response. After one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output.
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