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Neuro-pharmacological effects of Crinum zeylanicum in mice

Author(s): Adeniyi Yahaya Tijani | Oluwakanyinsola Adeola Salawu | Good-luck Jaiyeoba | Joseph Akponso Anuka | Isah Marte Hussaini

Journal: Avicenna Journal of Phytomedicine
ISSN 2228-7930

Volume: 2;
Issue: 3;
Start page: 162;
Date: 2012;
Original page

Keywords: Crinum Zeylanicum | Pentobarbitone | Psychosis | Sleep | Stereotype Behaviour

Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system.Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance.Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p
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