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New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines

Author(s): Raghunath B. Toche | Bhausaheb K. Ghotekar | Muddassar A. Kazi | Shivaraj P. Patil | Madhukar N. Jachak

Journal: Scholarly Research Exchange
ISSN 1687-8299

Volume: 2008;
Date: 2008;
Original page

A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α-acetyl-γ-butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.

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