Author(s): Raghunath B. Toche | Bhausaheb K. Ghotekar | Muddassar A. Kazi | Shivaraj P. Patil | Madhukar N. Jachak
Journal: Scholarly Research Exchange
ISSN 1687-8299
Volume: 2008;
Date: 2008;
Original page
ABSTRACT
A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α-acetyl-γ-butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.
Journal: Scholarly Research Exchange
ISSN 1687-8299
Volume: 2008;
Date: 2008;
Original page
ABSTRACT
A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α-acetyl-γ-butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.
