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Niosomes: The ultimate drug carrier

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Author(s): Dubey Subodh1*, Jain Amit1, Mehta S.C.2, Gupta Pavan3, Jain Sandeep3, Sahu Jagdish1

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 72;
Date: 2010;
Original page

Keywords: Niosomes | Encapsulation | Surfactants | Vesicles

ABSTRACT
Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The method of preparation of niosome is based on liposome technology. The basic process of preparation is the same i.e. hydration by aqueous phase of the lipid phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. After preparing niosomal dispersion, unentrapped drug is separated by dialysis centrifugation or gel filtration. A method of in-vitro release rate study includes the use of dialysis tubing. Niosomes are unilamellar or multilamellar vesicles formed from synthetic non-ionic surfactants. Niosomal drug delivery is potentially applicable to many pharmacological agents for their action against various diseases.

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