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Node of Ranvier disruption as a cause of neurological diseases

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Author(s): Keiichiro Susuki

Journal: ASN Neuro
ISSN 1759-0914

Volume: 5;
Issue: 3;
Start page: e00118;
Date: 2013;
Original page

Keywords: axon–glial interactions | ion channel | neurological disease | node of Ranvier

ABSTRACT
Dysfunction and/or disruption of nodes of Ranvier are now recognized as key contributors to the pathophysiology of various neurological diseases. One reason is that the excitable nodal axolemma contains a high density of Nav (voltage-gated Na+ channels) that are required for the rapid and efficient saltatory conduction of action potentials. Nodal physiology is disturbed by altered function, localization, and expression of voltage-gated ion channels clustered at nodes and juxtaparanodes, and by disrupted axon–glial interactions at paranodes. This paper reviews recent discoveries in molecular/cellular neuroscience, genetics, immunology, and neurology that highlight the critical roles of nodes of Ranvier in health and disease.
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