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Noncoding RNA localisation mechanisms in chromatin regulation

Author(s): Kanhere Aditi | Jenner Richard G

Journal: Silence
ISSN 1758-907X

Volume: 3;
Issue: 1;
Start page: 2;
Date: 2012;
Original page

Keywords: noncoding RNA | transcription factor | RNA-protein interaction | chromatin | X inactivation

Abstract An important challenge in biology has been to understand how cell-type-specific expression programs are orchestrated through regulated access to chromatin. Knowledge of the interaction between noncoding RNAs (ncRNAs) and chromatin regulators has the potential to help answer such questions, but how ncRNAs target chromatin regulators to specific sites in the genome is not well understood. Recently, Jeon and Lee proposed that DNA-binding proteins act as a bridge between ncRNAs and their target sites in chromatin. In this minireview, we examine their findings and place them in the wider context of how chromatin regulator-RNA complexes are targeted to specific sites in chromatin.
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