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A NOVEL AND INDUSTRIAL APPROACH FOR THE SYNTHESIS OF VALSARTAN Ein neues und INDUSTRIAL Methode zur Synthese von Valsartan

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Author(s): Rajarshi N. Patel1,Dinesh S.Patel1,Ravi B.Patel1 and Ketan S.Patel

Journal: Heterocyclic Letters
ISSN 2231-3087

Volume: 3;
Issue: 4;
Start page: 513;
Date: 2013;
Original page

Keywords: Antihypertensive therapy; aryl bromide; Negishi coupling;tetrazole;valsartan | Diovan

ABSTRACT
An economical synthesis of the angiotensin-II substance valsartan (DiovanĀ®) is bestowed. Directed ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) and its Negishi coupling with aryl bromide five square measure the key steps of the synthesis. This methodology overcomes several of the drawbacks related to antecedently rumored syntheses.

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