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A novel method of synthesis of certain indole-3-aldehydes and their thiosemicarbazones as potential anticancer drugs

Author(s): P.V.S.Naidu | Prakash.MMS.Kinthada | Y.L.N.Murthy

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 02;
Issue: 04;
Start page: 92;
Date: 2011;
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Keywords: Anxiolytic | Crataegusoxycantha | Elevated plus maze | Light dark test | Actophotometer | GABA

Indole and its heterocyclic fused derivatives are found to be a potential anticancer, antitumor and antioxidant intermediates. In view of this, it was considered worthwhile; to synthesize Thiazole substituted Indole derivatives as potentially biologically active molecules. In our present work, simple and substituted Indole (1) on Vilsmeier-Haack formylation gave Indole-3-aldehyde(2). Treatment of (2) with thiosemicarbazide in refluxing methanol containing acetic acid gave indole-3-aldehyde thiosemicarbozone with a view of synthesizing their transtinal metal complexes with platinum (Pt), Palladium (Pd), Gold (Au) and Ruthenium (Ru). The precursors, the derivatives/Analogues and the transitional metal complexes of Indole derivatives are excellent candidates as anticancer drugs.
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