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Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

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Author(s): Juliane Menezes | Mariana Emerenciano | Flávia Pimenta | Gilson Guedes Filho | Isis Q. Magalhães | Mariana Sant’Ana | Marina Lipkin Vasquez | Ilana Zalcberg Renault | Maria S. Pombo-de-Oliveira

Journal: Clinical Medicine : Blood Disorders
ISSN 1178-2269

Volume: 1;
Start page: 27;
Date: 2008;
Original page

Keywords: acute myeloid leukemia | pregnancy | AML1/ETO | FLT3 mutation

ABSTRACT
Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15–17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.
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