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The Oncogene Mcts1

Author(s): Ali Hachem | Suvobroto Nandi

Journal: Translational Oncogenomics
ISSN 1177-2727

Volume: 2;
Start page: 79;
Date: 2007;
Original page

Keywords: oncogene | cell cycle | DNA damage | angiogenesis | pseudogene

The oncogene MCTS1, discovered as an amplified product in a subset of T-cell lymphoma lines, has been implicated in cell cycle progression and conferring a growth advantage in lymphomas and breast cancer. Recent research shows that it modulates the MAPK pathway and acts as a translational activator both in vivo and in vitro. In breast cancer cells, expression of MCTS1 confers aggressive properties and inhibits apoptosis. This article will review these data and its implications on our understanding of cancer.
RPA Switzerland

RPA Switzerland

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