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Oncoproteomics: New trends in analytical techniques

Author(s): Girish Gupta | Nikhil Gupta | Mayank Gupta | Soham Trivedi | Prasad Patil | Vamsi Krishna K | Hipal Gaudani | Gomase V.S.

Journal: International Journal of Drug Discovery
ISSN 0975-4423

Volume: 1;
Issue: 2;
Start page: 05;
Date: 2009;
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Keywords: Oncoproteomics | Genomics | Proteomics | NMR | MS | GC

Oncoproteomics is the study of proteins and their interactions in a cancer cell by proteomictechnologies and has the potential to revolutionize clinical practice, including cancer diagnosis.Oncoproteomics screening based on proteomic platforms as a complement to histopathology, individualizedselection of therapeutic combinations that target the entire cancer-specific protein network, real-timeassessment of therapeutic efficacy and toxicity and rational modulation of therapy based on changes in thecancer protein network associated with prognosis and drug resistance. Oncoproteomics refers to theapplication of proteomic technologies in oncology and parallels the related field of oncogenomics. Thechallenges ahead and perspectives of oncoproteomics for biomarkers development are also addressed.With a wealth of information that can be applied to a broad spectrum of biomarker research projects servesas a reference for biomarker researchers, scientists working in proteomics and bioinformatics, oncologists,pharmaceutical scientists, biochemists, biologists, and chemists.
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