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One in Three: Congenital Bent Bone Disease and Intermittent Hyperthermia in Three Siblings with Stuve-Wiedemann Syndrome

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Author(s): Roshan Koul | Adila Al-Kindy | Renjith Mani | Dilip Sankhla | Amna Al-Futaisi

Journal: Sultan Qaboos University Medical Journal : SQUMJ
ISSN 2075-051X

Volume: 13;
Issue: 2;
Start page: 301;
Date: 2013;
Original page

Keywords: Stuve-Weidemann syndrome | Schwartz-Jampel syndrome | Myotonia | Pyrexia | Case report | Oman.

ABSTRACT
Stuve-Wiedemann syndrome (STWS) is a rare disorder characterised by congenital bowing of the long bones, contractures of the joints, neonatal onset of respiratory distress, sucking and swallowing difficulties, dysautonomia presenting as episodic hyperthermia, and usually an early death. Three siblings from a consanguineous marriage presented with similar clinical features over 16 years. STWS was established with their last child at the beginning of 2012. All the children exhibited the onset of STWS in the neonatal period with fever and generalised hypotonia. Examinations of all the infants revealed camptodactyly, micrognathia, bent long bones with wide metaphyses, and hypotonia. Only the second affected child had myotonia, demonstrated by electromyography. Unusual pyrexia as a presenting feature in this syndrome needs early recognition so that extensive and elaborateinvestigations can be avoided. The disorder is usually caused by a mutation in the leukaemia inhibitory factor receptor gene.

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