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An online conserved SSR discovery through cross-species comparison

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Author(s): Tun-Wen Pai | Chien-Ming Chen | Meng-Chang Hsiao | Ronshan Cheng | Wen-Shyong Tzou | Chin-Hua Hu

Journal: Advances and Applications in Bioinformatics and Chemistry
ISSN 1178-6949

Volume: 2009;
Issue: default;
Start page: 23;
Date: 2009;
Original page

ABSTRACT
Tun-Wen Pai1, Chien-Ming Chen1, Meng-Chang Hsiao1, Ronshan Cheng2, Wen-Shyong Tzou3, Chin-Hua Hu31Department of Computer Science and Engineering; 2Department of Aquaculture, 3Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan, Republic of ChinaAbstract: Simple sequence repeats (SSRs) play important roles in gene regulation and genome evolution. Although there exist several online resources for SSR mining, most of them only extract general SSR patterns without providing functional information. Here, an online search tool, CG-SSR (Comparative Genomics SSR discovery), has been developed for discovering potential functional SSRs from vertebrate genomes through cross-species comparison. In addition to revealing SSR candidates in conserved regions among various species, it also combines accurate coordinate and functional genomics information. CG-SSR is the first comprehensive and efficient online tool for conserved SSR discovery.Keywords: microsatellites, genome, comparative genomics, functional SSR, gene ontology, conserved region
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