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Palladium-Catalyzed Polyfluorophenylation of Porphyrins with Bis(polyfluorophenyl)zinc Reagents

Author(s): Noriaki Sugita | Satoshi Hayashi | Sawa Ishii | Toshikatsu Takanami

Journal: Catalysts
ISSN 2073-4344

Volume: 3;
Issue: 4;
Start page: 839;
Date: 2013;
Original page

Keywords: porphyrin | polyfluorophenylation | bis(polyfluorophenyl)zinc | palladium | cross-coupling

A facile and efficient method for the synthesis of pentafluorophenyl- and related polyfluorophenyl-substituted porphyrins has been achieved via palladium-catalyzed cross-coupling reactions of brominated porphyrins with bis(polyfluorophenyl)zinc reagents. The reaction is applicable to a variety of free-base bromoporphyrins, their metal complexes, and a number of bis(polyfluorophenyl)zinc reagents.

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