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Palonosetron: A novel approach to control postoperative nausea and vomiting in day care surgery

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Author(s): Bajwa Sukhminderjit | Bajwa Sukhwinder | Kaur Jasbir | Sharma Veenita | Singh Amarjit | Singh Anita | Goraya SPS | Parmar S | Singh Kamaljit

Journal: Saudi Journal of Anaesthesia
ISSN 1658-354X

Volume: 5;
Issue: 1;
Start page: 19;
Date: 2011;
Original page

Keywords: Day care surgery | palonosetron | ondansetron | ponv0

ABSTRACT
Background: Postoperative nausea and vomiting (PONV) is one of the complications which hamper the successful implementation of day care surgical procedure in spite of the availability of so many antiemetic drugs and regimens for its prevention. The aim was to compare the prophylactic effects of intravenously (IV) administered ondansetron and palonosetron on PONV prevention in patients undergoing laparoscopic gynecological surgery under general anesthesia. Methods: A prospective double-blind study comprised of 60 ASAI/II female patients between the age group of 25 and 40 years was carried out in the Departments of Anesthesiology and Obstetrics and Gynecology of our institute. Patients were randomly divided into two groups of 30 patients each in a double-blind manner. Group I received 8 mg of inj. ondansetron IV while group II received inj. palonosetron 0.075 mg IV 5 minutes before the induction of anesthesia. The need for rescue antiemetics, episodes of PONV and other side effects were observed for 6 hours in the postanesthesia care unit and thereafter complaints were received on phone after the discharge. At the end of study, results were compiled and statistical data was subjected to statistical analysis using Student two-tailed ′t′ and c2 test and value of P
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