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Pancreatoprotection of Malate-Containing Infusion Solutions in Experimental Hemorrhagic Shock

Author(s): А.Y. Yakovlev | L.B. Snopova | Т.А. Galanina | D.V. Ryabikov | D.М. Protasov

Journal: Sovremennye Tehnologii v Medicine
ISSN 2076-4243

Volume: 5;
Issue: 2;
Start page: 25;
Date: 2013;
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Keywords: Hemorrhagic shock | Malate | Sterofundin isotonic | Isotonic Sterofundin | Pancreas

The aim of the investigation was to study in experiment the effect of Sterofundin isotonic on the development of post-hemorrhagic damage of the pancreas.Materials and Methods. The experiments were carried out on 36 male Wistar rats weighing 230–250 g. Hemorrhagic shock was stimulated by acute massive hemorrhage to the extent of 2.5 mL/100 g at rate of 2 mL/min. The blood loss an hour later was followed by the replacement of hypovolemia within 60 min by 200% of the lost volume: in control group — by Ringer’s solution, in test group — by Sterofundin isotonic. Then there was performed reinfusion in the volume of 70% of blood loss. On day 1 and 3 after hemorrhagic shock we assessed the laboratory findings and morphological changes of the pancreas.Results. There was found pancreatoprotective action of isotonic Sterofundin, a malate-containing blood substitute in infusion therapy of experimental hemorrhagic shock.
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