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Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action

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Author(s): Christina Leah B. Kline | Wafik S. El-Deiry

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 6;
Issue: 8;
Start page: 988;
Date: 2013;
Original page

Keywords: colorectal cancer | personalized medicine | genetic polymorphisms

ABSTRACT
The use of pharmaceuticals for colon cancer treatment has been increasingly personalized, in part due to the development of new molecular tools. In this review, we discuss the old and new colon cancer chemotherapeutics, and the parameters that have been shown to be predictive of efficacy and safety of these chemotherapeutics. In addition, we discuss how alternate pharmaceuticals have been developed in light of a potential lack of response or resistance to a particular chemotherapeutic.
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