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Pharmacogenetics of oral anticoagulant therapy

Author(s): Tudor R. Pop | Daciana N. Chirilă | Anca D. Buzoianu

Journal: Human & Veterinary Medicine
ISSN 2066-7655

Volume: 5;
Issue: 1;
Start page: 9;
Date: 2013;
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Keywords: oral anticoagulant therapy | pharmacogenetics | CYP2C9 | VKORC1 | algorithms

Acenocoumarol and warfarin are among the most frequently used oral anticoagulants (OA) in the entire world. Their therapeutic indexis narrow and there are many factors, including genetic ones, which interfere with their metabolism. The CYP2C9 and VKORC1 polymorphismsconstitute the most important genetic factors that impede the correct anticoagulation. Algorithms which combine clinical and geneticparameters in order to predict a safe therapeutic dose of OA might be useful in reducing the risk of adverse effects.

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