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Pharmacological Profiles of Oligomerized μ-Opioid Receptors

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Author(s): Cynthia Wei-Sheng Lee | Ing-Kang Ho

Journal: Cells
ISSN 2073-4409

Volume: 2;
Issue: 4;
Start page: 689;
Date: 2013;
Original page

Keywords: μ-opioid receptor | bivalent ligand | receptor oligomerization

ABSTRACT
Opioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: μ-, δ-, κ-opioid and opioid receptor-like 1 receptors. Bivalent ligands targeted to the oligomerized opioid receptors might be the key to developing analgesics without undesired side effects and obtaining effective treatment for opioid addicts. In this review we will update the biological effects of μ-opioids on homo- or hetero-oligomerized μ-opioid receptor and discuss potential mechanisms through which bivalent ligands exert beneficial effects, including adenylate cyclase regulation and receptor-mediated signaling pathways.
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