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Phospho-onco-proteomics

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Author(s): Gomase V.S. | Shyamkumar Krishnan

Journal: International Journal of Genetics
ISSN 0975-2862

Volume: 1;
Issue: 1;
Start page: 06;
Date: 2009;
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Keywords: Phosphoproteomics | Phosphorylation | Analytical technologies | transcriptomics

ABSTRACT
Phosphoproteomics is the global analysis of protein phosphorylation, holds greatpromise for the discovery of cell signaling events that link changes in dynamics of proteinphosphorylation to the progression of various diseases, particularly cancer and diabetes.Proteomic research first came for research with the introduction of two-dimensional gelelectrophoresis. Proteomics has been increasingly applied to oncology research with the widespreadintroduction of mass spectrometry and protein-chip. Applying proteomics to foster animproved understanding of cancer pathogenesis develop new tumor biomarkers for diagnosis,and early detection using proteomic portrait of samples. The study of Phospho-onco-proteomicsprovides a better understanding of cancer diagnosis.
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