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Photochemically induced ischemic stroke in rats

Author(s): Schmidt Antje | Hoppen Maike | Strecker Jan-Kolja | Diederich Kai | Schäbitz Wolf-Rüdiger | Schilling Matthias | Minnerup Jens

Journal: Experimental & Translational Stroke Medicine
ISSN 2040-7378

Volume: 4;
Issue: 1;
Start page: 13;
Date: 2012;
Original page

Keywords: Photothrombosis | Experimental stroke | Animal model

Abstract Background Photothrombosis was introduced as a model of ischemic stroke by Watson et al. in 1985. In the present paper, we describe a protocol to induce photothrombotic infarcts in rats. Findings The photosensitive dye Bengal Rose is intravenously administered and a laser beam is stereotactically positioned onto the skull. Illumination through the intact skull leads to local activation of Bengal Rose, which results in free radical formation, disturbance of endothelial function and thrombus formation in illuminated small cortical vessels. Conclusions Photochemically induced infarcts cause long-term sensorimotor deficits, allow long-term survival and are particularly suitable to assess the effectiveness of neuroregenerative therapies in chronic stroke studies.
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