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Physical chemistry evaluation of magistral capsules containing prednisone in the city of Erechim, RS

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Author(s): Roberta Barancelli | João Ronaldo Notargiacomo Ferreira

Journal: Evidência : Ciência e Biotecnologia - Interdisciplinar
ISSN 1519-5287

Volume: 7;
Issue: 1;
Start page: 51;
Date: 2007;

ABSTRACT
Currently the manipulation’s pharmacy exercises an extreme and important function in relation to the health care. The control of quality test represents worthy information which guarantee that pharmaceutics formulation have its efficacy proved. The prednisone (PD) is a pro-drug which becomes pharmacologically activated after metabolized inside the organism. It is a steroidal anti-inflammatory, and its action is widely referred due to the inhibition of cyclocygenase-2. It has been used for pain relief and inflammation combat. Considering solid medications, of oral use, as those which can present the most problems in relation to the bioavailability, therefore become necessary analyze the impact of this factor about the drug dissolution from on the pharmaceutics form. Tests have been carry out appointed from the drug monograph, and others parameters defined by the America (USP, 29) and Brazilian (IV ed) Pharmacopoeia, to control the prednisone physic-chemical quality. Also the profiles of dissolution of skillful and compressed capsules had been evaluated. According to the results obtained, as the SQR, as the samples, both have fulfilled with the pharmacopoeia specification accomplished in the test of medium weight (30N), friability (
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